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KMID : 1161420180210040400
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Journal of Medicinal Food
2018 Volume.21 No. 4 p.400 ~ p.407
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Efficacy and Safety of Tremella fuciformis in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial
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Ban Soon-Hyun
Lee Su-Ji L.
Jeong Hyeon-Seok S.
Lim Soo-Mee
Park Shin-Won
Hong Young-Sun
Kim Ji-Eun E.
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Abstract
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The efficacy and safety of Tremella fuciformis (TF) as a nutritional supplement were assessed in individuals with subjective cognitive impairment (SCI). Seventy-five individuals with SCI were enrolled in an 8-week, randomized, double-blind, placebo-controlled trial of TF (600?mg/day, n?=?30 or 1200?mg/day, n?=?30) or placebo (n?=?15). The primary outcome measure was changes in total scores of the subjective memory complaint questionnaire. The secondary outcome measures were changes in performance on short-term memory and executive functions, which were assessed using standardized cognitive tests. In addition, voxel-based morphometry was performed to examine the effects of TF on changes in gray matter volume. The individuals in the TF group showed greater improvements in the total scores on the subjective memory complaint questionnaire compared with those in the placebo group. There were also significantly greater improvements in short-term memory and executive functions in the TF group relative to the placebo group. Exploratory analysis demonstrated that there were significant group-by-visit interactions on the left precuneus, right supramarginal gyrus, right middle frontal gyrus, and right postcentral gyrus at corrected P?
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KEYWORD
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cognitive impairment, executive function, short-term memory, subjective, subjective memory complaint, Tremella fuciformis
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